AlphaGene Protein Design Studio prepared demonstration assets
Prepared: 2026-08-27

The three backbone-complex PDB files are tutorial outputs from the
RosettaCommons RFdiffusion repository, pinned to commit:
d1e73869925de2d189081acb3a597ff98c30200d

Source directory:
https://github.com/RosettaCommons/RFdiffusion/tree/d1e73869925de2d189081acb3a597ff98c30200d/tutorials/protein_binder_design

The tutorial target is derived from PDB 7SSZ. The demonstration PDB files
contain a designed binder backbone in chain A and the prepared target in
chain B. Tutorial materials are credited to Diego Lopez Mateos, Matthew
Hvasta, and Kush Narang. RFdiffusion is copyright 2023 University of
Washington and was developed at the Institute for Protein Design.

AlphaGene Labs generated the paired FASTA sequences from these public
backbones with ProteinMPNN model v_48_020, git commit
8907e6671bfbfc92303b5f79c4b5e6ce47cdef57. The Lys-Tyr motif positions
were held fixed. ProteinMPNN is copyright 2022 Justas Dauparas.

The prepared assets do not include an RFdiffusion trajectory, AlphaFold,
ColabFold, or ESMFold output. The on-page transition is explicitly an
illustration and is not presented as model timesteps. No candidate has been
experimentally tested.

See RFDIFFUSION_LICENSE.txt and PROTEINMPNN_LICENSE.txt in this directory.